Hexarelin
Hexarelin is a synthetic hexapeptide, His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2, derived from GHRP-6 and acting at the ghrelin receptor.
- TypePeptide
- FormulaC47H58N12O6
- Average mass887.04 g/mol
- CAS140703-51-1
- Vesta listings2
Reference page for laboratory use · updated 2026-10-30
Overview
Hexarelin at a glance
Hexarelin is the 2-methyl-tryptophan analogue of GHRP-6. Besides its growth hormone-releasing activity it has been studied for effects mediated by cardiac receptors, and reviews of its cardiovascular pharmacology are available.
It is supplied here as a research material.
Structure
The only change from GHRP-6 is a methyl group on the indole ring of the D-tryptophan, giving a mass 14.016 Da higher.
Identity
Identity data
| Name | Hexarelin |
|---|---|
| Also written as | Examorelin |
| Type | Peptide |
| Research area | Growth hormone axis peptides |
| Molecular formula | C47H58N12O6 |
| Monoisotopic mass | 886.4602 Da |
| Average molecular weight | 887.04 g/mol |
| CAS number | 140703-51-1, 208251-52-9 |
| Sequence | His-2-Me-Trp-Ala-Trp-Phe-Lys-NH2 |
| PubChem record | CID 6918297 |
The formula was calculated independently from the written sequence and matches the PubChem record exactly. Reference data retrieved on 2026-10-30. Compare these values with the batch certificate of analysis, using the compound identity file template.
Expected values
Mass spectrometry reference
Ions calculated from the monoisotopic mass 886.4602 Da. Use them to check an LC-MS result; for larger peptides the instrument usually reports a deconvoluted mass close to 887.0 Da instead.
| Ion | m/z |
|---|---|
| [M+H]+ | 887.4675 |
| [M+2H]2+ | 444.2374 |
| [M+Na]+ | 909.4494 |
| [M+K]+ | 925.4234 |
Read the guide to average and monoisotopic mass for how these values are calculated.
Quality
Analytical notes for batch documents
- The mass difference to GHRP-6 (14.016 Da) is small but easy to resolve by mass spectrometry; confirm that the COA does not show the GHRP-6 mass.
- The values in the table are for the free peptide.
- Mass shifts to look for in this sequence: tryptophan oxidation (+15.995 Da).
- The molecular weight of a vial of powder includes counter-ions and water; the share of the powder that is peptide is the net peptide content.
Terms used on this page: Mass spectrometry, Peptide.
Vesta listings
Hexarelin formats and prices
| Product | Per vial | SKU | Price per kit | Price per vial |
|---|---|---|---|---|
| Hexarelin | 2 mg | HX2 | $69.03 | $6.90 |
| Hexarelin | 5 mg | HX5 | $128.73 | $12.87 |
Prices are per kit of 10 vials in US dollars. Shipping is paid by the customer and is shown in the cart. Volume savings of 5 %, 8 % and 10 % apply from $350.00, $600.00 and $1,000.00. See the full price list.
Published literature
Selected scientific literature
Bibliographic details were read from PubMed on 2026-10-30. The papers are listed for scientific reference; Vesta makes no claim about the use of its research materials in people or animals.
- The cardiovascular action of hexarelinMao Y, Tokudome T, Kishimoto I et al. · J Geriatr Cardiol · 2014 · PMID 25278975
- Implications of ghrelin and hexarelin in diabetes and diabetes-associated heart diseasesMosa RM, Zhang Z, Shao R et al. · Endocrine · 2015 · PMID 25645463
Questions
Frequently asked questions
What is Hexarelin?
Hexarelin is a synthetic hexapeptide, His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2, derived from GHRP-6 and acting at the ghrelin receptor.
What is the molecular weight of Hexarelin?
Hexarelin has the formula C47H58N12O6, an average molecular weight of 887.04 g/mol and a monoisotopic mass of 886.4602 Da. A salt form, a different counter-ion or a metal complex changes the molecular weight printed on a certificate of analysis, so compare like with like.
How can I check the identity of a batch of Hexarelin?
Compare the intact mass measured by LC-MS with the expected values on this page, for example [M+2H]2+ at m/z 444.2374. Confirm that one main HPLC peak carries that mass and that the batch code on the report matches the vial. The guides on mass spectrometry and on certificates of analysis explain each step.
Which Hexarelin products does Vesta list?
Vesta lists 2 products for Hexarelin: 2 mg, 5 mg per vial in kits of 10 vials. Prices are shown per kit in US dollars, and shipping is paid by the customer.