GHRP-6
GHRP-6 is a synthetic hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, and one of the first synthetic ghrelin-receptor agonists.
- TypePeptide
- FormulaC46H56N12O6
- Average mass873.01 g/mol
- Vesta listings3
Reference page for laboratory use · updated 2026-10-30
Overview
GHRP-6 at a glance
GHRP-6 was among the earliest growth hormone-releasing peptides discovered. It is used as a reference compound in ghrelin-receptor studies, and detection methods for it in biological samples are published.
Vesta lists it as the acetate salt.
Structure
It differs from GHRP-2 by its N-terminal histidine and D-tryptophan. The sequence-derived formula matches PubChem.
Identity
Identity data
| Name | GHRP-6 |
|---|---|
| Also written as | Growth hormone releasing peptide-6 |
| Type | Peptide |
| Research area | Growth hormone axis peptides |
| Molecular formula | C46H56N12O6 |
| Monoisotopic mass | 872.4446 Da |
| Average molecular weight | 873.01 g/mol |
| Sequence | His-Trp-Ala-Trp-Phe-Lys-NH2 |
| PubChem record | CID 4345065 |
The formula was calculated independently from the written sequence and matches the PubChem record exactly. Reference data retrieved on 2026-10-30. Compare these values with the batch certificate of analysis, using the compound identity file template.
Expected values
Mass spectrometry reference
Ions calculated from the monoisotopic mass 872.4446 Da. Use them to check an LC-MS result; for larger peptides the instrument usually reports a deconvoluted mass close to 873.0 Da instead.
| Ion | m/z |
|---|---|
| [M+H]+ | 873.4519 |
| [M+2H]2+ | 437.2296 |
| [M+Na]+ | 895.4338 |
| [M+K]+ | 911.4078 |
Read the guide to average and monoisotopic mass for how these values are calculated.
Quality
Analytical notes for batch documents
- Tryptophan residues can oxidise, giving +15.995 Da and +31.990 Da species.
- The acetate salt is heavier than the free peptide shown in the table; compare like with like when you read a COA.
- Mass shifts to look for in this sequence: tryptophan oxidation (+15.995 Da).
- The molecular weight of a vial of powder includes counter-ions and water; the share of the powder that is peptide is the net peptide content.
Terms used on this page: Acetate salt, Peptide.
Vesta listings
GHRP-6 formats and prices
| Product | Per vial | SKU | Price per kit | Price per vial |
|---|---|---|---|---|
| GHRP-6 Acetate | 5 mg | G65 | $63.43 | $6.34 |
| GHRP-6 Acetate | 10 mg | G610 | $95.15 | $9.52 |
| GHRP-6 Acetate | 15 mg | G615 | $128.73 | $12.87 |
Prices are per kit of 10 vials in US dollars. Shipping is paid by the customer and is shown in the cart. Volume savings of 5 %, 8 % and 10 % apply from $350.00, $600.00 and $1,000.00. See the full price list.
Published literature
Selected scientific literature
Bibliographic details were read from PubMed on 2026-10-30. The papers are listed for scientific reference; Vesta makes no claim about the use of its research materials in people or animals.
- Regulation of growth hormone secretion by the growth hormone releasing hexapeptide (GHRP-6)Micic D, Mallo F, Peino R et al. · J Pediatr Endocrinol · 1993 · PMID 7920995
- Ghrelin and GHRP-6 enhance electrical and secretory activity in GC somatotropesDominguez B, Felix R, Monjaraz E et al. · Biochem Biophys Res Commun · 2007 · PMID 17481583
- Detection of GHRP-2 and GHRP-6 in urine samples from athletesCox HD, Hughes CM, Eichner D et al. · Drug Test Anal · 2015 · PMID 25809000
Questions
Frequently asked questions
What is GHRP-6?
GHRP-6 is a synthetic hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, and one of the first synthetic ghrelin-receptor agonists.
What is the molecular weight of GHRP-6?
GHRP-6 has the formula C46H56N12O6, an average molecular weight of 873.01 g/mol and a monoisotopic mass of 872.4446 Da. A salt form, a different counter-ion or a metal complex changes the molecular weight printed on a certificate of analysis, so compare like with like.
How can I check the identity of a batch of GHRP-6?
Compare the intact mass measured by LC-MS with the expected values on this page, for example [M+2H]2+ at m/z 437.2296. Confirm that one main HPLC peak carries that mass and that the batch code on the report matches the vial. The guides on mass spectrometry and on certificates of analysis explain each step.
Which GHRP-6 products does Vesta list?
Vesta lists 3 products for GHRP-6: 5 mg, 10 mg, 15 mg per vial in kits of 10 vials. Prices are shown per kit in US dollars, and shipping is paid by the customer.