Metabolites and small molecules
5-Amino-1MQ
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule compound used as a tool inhibitor of nicotinamide N-methyltransferase (NNMT).
- TypeSmall molecule
- FormulaC10H11N2+
- Average mass159.21 g/mol
- CAS685079-15-6
- Vesta listings3
Reference page for laboratory use · updated 2026-10-30
Overview
5-Amino-1MQ at a glance
NNMT methylates nicotinamide and is studied in metabolism and cancer biology. Published work on small-molecule NNMT inhibitors covers their membrane permeability, selectivity and mechanism, and a recent review in Trends in Pharmacological Sciences discusses the prospects for NNMT inhibitors.
In the laboratory it is used as a tool compound when NNMT activity needs to be blocked in cell or enzyme assays.
Structure
PubChem lists the compound as the cation C10H11N2+ (159.21). Because it is a quinolinium cation it is supplied as a salt with a counter-ion, so the molecular weight printed on a COA will be higher than the cation mass.
Identity
Identity data
| Name | 5-Amino-1MQ |
|---|---|
| Also written as | 5-amino-1-methylquinolinium |
| Type | Small molecule |
| Research area | Metabolites and small molecules |
| Molecular formula | C10H11N2+ |
| Monoisotopic mass | 159.0922 Da |
| Average molecular weight | 159.21 g/mol |
| CAS number | 685079-15-6 |
| PubChem record | CID 950107 |
The formula comes from the PubChem record; monoisotopic mass is calculated from the formula and the average mass uses standard atomic weights. Reference data retrieved on 2026-10-30. Compare these values with the batch certificate of analysis, using the compound identity file template.
Expected values
Mass spectrometry reference
Ions calculated from the monoisotopic mass 159.0922 Da. Use them to check an LC-MS result; for larger peptides the instrument usually reports a deconvoluted mass close to 159.2 Da instead.
| Ion | m/z |
|---|---|
| [M]+ (the cation itself) | 159.0917 |
Read the guide to average and monoisotopic mass for how these values are calculated.
Quality
Analytical notes for batch documents
- Mass spectrometry detects the cation itself at m/z 159.09; the counter-ion is not seen in positive mode.
- Ask which counter-ion is present and for an HPLC-UV chromatogram, as the compound absorbs strongly in the UV.
- The molecular weight of a vial of powder includes counter-ions and water; the share of the powder that is peptide is the net peptide content.
Terms used on this page: Counter-ion, Mass spectrometry.
Vesta listings
5-Amino-1MQ formats and prices
| Product | Per vial | SKU | Price per kit | Price per vial |
|---|---|---|---|---|
| 5-AMINO-1MQ | 5 mg | 5AM | $29.85 | $2.99 |
| 5-AMINO-1MQ | 10 mg | 10AM | $59.70 | $5.97 |
| 5-AMINO-1MQ | 50 mg | 50AM | $119.40 | $11.94 |
Prices are per kit of 10 vials in US dollars. Shipping is paid by the customer and is shown in the cart. Volume savings of 5 %, 8 % and 10 % apply from $350.00, $600.00 and $1,000.00. See the full price list.
Published literature
Selected scientific literature
Bibliographic details were read from PubMed on 2026-10-30. The papers are listed for scientific reference; Vesta makes no claim about the use of its research materials in people or animals.
- Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in miceNeelakantan H, Vance V, Wetzel MD et al. · Biochem Pharmacol · 2018 · PMID 29155147
- Emerging opportunities for nicotinamide N-methyltransferase (NNMT) inhibitor clinical translationPuleo N, Allega MF, Niemann CU et al. · Trends Pharmacol Sci · 2026 · PMID 42067476
Questions
Frequently asked questions
What is 5-Amino-1MQ?
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule compound used as a tool inhibitor of nicotinamide N-methyltransferase (NNMT).
What is the molecular weight of 5-Amino-1MQ?
5-Amino-1MQ has the formula C10H11N2+, an average molecular weight of 159.21 g/mol and a monoisotopic mass of 159.0922 Da. A salt form, a different counter-ion or a metal complex changes the molecular weight printed on a certificate of analysis, so compare like with like.
How can I check the identity of a batch of 5-Amino-1MQ?
Compare the intact mass measured by LC-MS with the expected values on this page, for example [M]+ (the cation itself) at m/z 159.0917. Confirm that one main HPLC peak carries that mass and that the batch code on the report matches the vial. The guides on mass spectrometry and on certificates of analysis explain each step.
Which 5-Amino-1MQ products does Vesta list?
Vesta lists 3 products for 5-Amino-1MQ: 5 mg, 10 mg, 50 mg per vial in kits of 10 vials. Prices are shown per kit in US dollars, and shipping is paid by the customer.