PE-22-28
PE-22-28 is a seven-residue peptide (Gly-Val-Ser-Trp-Gly-Leu-Arg) that is described as a short peptide related to spadin, a sortilin-derived peptide that blocks the TREK-1 potassium channel.
- TypePeptide
- FormulaC35H55N11O9
- Average mass773.88 g/mol
- CAS1801959-12-5
- Vesta listings2
Reference page for laboratory use · updated 2026-10-30
Overview
PE-22-28 at a glance
Spadin was described in PLoS Biology in 2010 as a sortilin-derived peptide targeting TREK-1 channels. PE-22-28 is a shorter analogue based on the same region.
The literature on this specific peptide is limited, so it should be verified by independent analysis.
Structure
PubChem lists the peptide as glycyl-valyl-seryl-tryptophyl-glycyl-leucyl-arginine, and the calculated formula from that sequence matches the record.
Identity
Identity data
| Name | PE-22-28 |
|---|---|
| Also written as | Mini-spadin, Spadin analogue |
| Type | Peptide |
| Research area | Neuropeptide-derived peptides |
| Molecular formula | C35H55N11O9 |
| Monoisotopic mass | 773.4184 Da |
| Average molecular weight | 773.88 g/mol |
| CAS number | 1801959-12-5 |
| Sequence | Gly-Val-Ser-Trp-Gly-Leu-Arg |
| PubChem record | CID 165437303 |
The formula was calculated independently from the written sequence and matches the PubChem record exactly. Reference data retrieved on 2026-10-30. Compare these values with the batch certificate of analysis, using the compound identity file template.
Expected values
Mass spectrometry reference
Ions calculated from the monoisotopic mass 773.4184 Da. Use them to check an LC-MS result; for larger peptides the instrument usually reports a deconvoluted mass close to 773.9 Da instead.
| Ion | m/z |
|---|---|
| [M+H]+ | 774.4257 |
| [M+2H]2+ | 387.7165 |
| [M+Na]+ | 796.4076 |
| [M+K]+ | 812.3816 |
Read the guide to average and monoisotopic mass for how these values are calculated.
Quality
Analytical notes for batch documents
- The tryptophan residue is the main oxidation site (+15.995 Da).
- Expect [M+H]+ at m/z 774.43 and a weaker [M+2H]2+ at m/z 387.72.
- Mass shifts to look for in this sequence: tryptophan oxidation (+15.995 Da).
- The molecular weight of a vial of powder includes counter-ions and water; the share of the powder that is peptide is the net peptide content.
Terms used on this page: Peptide.
Vesta listings
PE-22-28 formats and prices
Prices are per kit of 10 vials in US dollars. Shipping is paid by the customer and is shown in the cart. Volume savings of 5 %, 8 % and 10 % apply from $350.00, $600.00 and $1,000.00. See the full price list.
Published literature
Selected scientific literature
Bibliographic details were read from PubMed on 2026-10-30. The papers are listed for scientific reference; Vesta makes no claim about the use of its research materials in people or animals.
- Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug designMazella J, Pétrault O, Lucas G et al. · PLoS Biol · 2010 · PMID 20405001
Questions
Frequently asked questions
What is PE-22-28?
PE-22-28 is a seven-residue peptide (Gly-Val-Ser-Trp-Gly-Leu-Arg) that is described as a short peptide related to spadin, a sortilin-derived peptide that blocks the TREK-1 potassium channel.
What is the molecular weight of PE-22-28?
PE-22-28 has the formula C35H55N11O9, an average molecular weight of 773.88 g/mol and a monoisotopic mass of 773.4184 Da. A salt form, a different counter-ion or a metal complex changes the molecular weight printed on a certificate of analysis, so compare like with like.
How can I check the identity of a batch of PE-22-28?
Compare the intact mass measured by LC-MS with the expected values on this page, for example [M+2H]2+ at m/z 387.7165. Confirm that one main HPLC peak carries that mass and that the batch code on the report matches the vial. The guides on mass spectrometry and on certificates of analysis explain each step.
Which PE-22-28 products does Vesta list?
Vesta lists 2 products for PE-22-28: 5 mg, 10 mg per vial in kits of 10 vials. Prices are shown per kit in US dollars, and shipping is paid by the customer.