Kisspeptin-10
Kisspeptin-10 is a ten-residue peptide amide (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2) that is the C-terminal fragment 45-54 of the kisspeptin precursor and binds the kisspeptin receptor (KISS1R, GPR54).
- TypePeptide
- FormulaC63H83N17O14
- Average mass1302.44 g/mol
- CAS374675-21-5
- Vesta listings2
Reference page for laboratory use · updated 2026-10-30
Overview
Kisspeptin-10 at a glance
Kisspeptin signalling is central to the control of the reproductive axis. Reviews cover its role in the hypothalamic-pituitary-gonadal axis, its metabolic regulation and its interaction with neurokinin B.
Kisspeptin-10 is the shortest fragment that keeps full receptor binding, which is why it is used as the reference peptide in receptor studies.
Structure
The C-terminal Arg-Phe-NH2 is essential for binding. The calculated formula matches PubChem exactly.
Identity
Identity data
| Name | Kisspeptin-10 |
|---|---|
| Also written as | Metastin 45-54 |
| Type | Peptide |
| Research area | Neuropeptide-derived peptides |
| Molecular formula | C63H83N17O14 |
| Monoisotopic mass | 1301.6305 Da |
| Average molecular weight | 1302.44 g/mol |
| CAS number | 374675-21-5 |
| Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
| PubChem record | CID 25240297 |
The formula was calculated independently from the written sequence and matches the PubChem record exactly. Reference data retrieved on 2026-10-30. Compare these values with the batch certificate of analysis, using the compound identity file template.
Expected values
Mass spectrometry reference
Ions calculated from the monoisotopic mass 1301.6305 Da. Use them to check an LC-MS result; for larger peptides the instrument usually reports a deconvoluted mass close to 1302.4 Da instead.
| Ion | m/z |
|---|---|
| [M+H]+ | 1302.6378 |
| [M+2H]2+ | 651.8225 |
| [M+Na]+ | 1324.6197 |
| [M+K]+ | 1340.5937 |
Read the guide to average and monoisotopic mass for how these values are calculated.
Quality
Analytical notes for batch documents
- The tryptophan residue can oxidise (+15.995 Da).
- Expect [M+H]+ at m/z 1302.64 and a strong [M+2H]2+ at m/z 651.82.
- Mass shifts to look for in this sequence: tryptophan oxidation (+15.995 Da); deamidation of Asn or Gln (+0.984 Da).
- The molecular weight of a vial of powder includes counter-ions and water; the share of the powder that is peptide is the net peptide content.
Terms used on this page: Peptide.
Vesta listings
Kisspeptin-10 formats and prices
| Product | Per vial | SKU | Price per kit | Price per vial |
|---|---|---|---|---|
| Kisspeptin-10 | 5 mg | KS5 | $67.16 | $6.72 |
| Kisspeptin-10 | 10 mg | KS10 | $104.48 | $10.45 |
Prices are per kit of 10 vials in US dollars. Shipping is paid by the customer and is shown in the cart. Volume savings of 5 %, 8 % and 10 % apply from $350.00, $600.00 and $1,000.00. See the full price list.
Published literature
Selected scientific literature
Bibliographic details were read from PubMed on 2026-10-30. The papers are listed for scientific reference; Vesta makes no claim about the use of its research materials in people or animals.
- Kisspeptin and neurokinin B: roles in reproductive healthKoysombat K, Tsoutsouki J, Patel AH et al. · Physiol Rev · 2025 · PMID 39813600
- The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and ReproductionXie Q, Kang Y, Zhang C et al. · Front Endocrinol (Lausanne) · 2022 · PMID 35837314
- Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblastsBilban M, Ghaffari-Tabrizi N, Hintermann E et al. · J Cell Sci · 2004 · PMID 15020672
Questions
Frequently asked questions
What is Kisspeptin-10?
Kisspeptin-10 is a ten-residue peptide amide (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2) that is the C-terminal fragment 45-54 of the kisspeptin precursor and binds the kisspeptin receptor (KISS1R, GPR54).
What is the molecular weight of Kisspeptin-10?
Kisspeptin-10 has the formula C63H83N17O14, an average molecular weight of 1302.44 g/mol and a monoisotopic mass of 1301.6305 Da. A salt form, a different counter-ion or a metal complex changes the molecular weight printed on a certificate of analysis, so compare like with like.
How can I check the identity of a batch of Kisspeptin-10?
Compare the intact mass measured by LC-MS with the expected values on this page, for example [M+2H]2+ at m/z 651.8225. Confirm that one main HPLC peak carries that mass and that the batch code on the report matches the vial. The guides on mass spectrometry and on certificates of analysis explain each step.
Which Kisspeptin-10 products does Vesta list?
Vesta lists 2 products for Kisspeptin-10: 5 mg, 10 mg per vial in kits of 10 vials. Prices are shown per kit in US dollars, and shipping is paid by the customer.